The concomitant use of OXYCONTIN and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of OXYCONTIN and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of OXYCONTIN is achieved see WARNINGS AND PRECAUTIONS. Cases of serotonin how addictive is oxycontin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs.
- An opioid antagonist, such as naloxone, must be available for reversal of opioid-induced respiratory depression in the neonate.
- If your symptoms improve with this medication, it confirms that you had an overdose.
- An overdose can occur if you take too much of an opioid or mix it with other addictive substances.
- When the drug attaches to a receptor, it reduces the number of pain signals that successfully reach a person’s brain, thus reducing the amount of pain they feel.
Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants
When this happens, the drug raises a person’s tolerance for pain and changes how they sense pain overall. While oxycodone does have legitimate medical uses as a pain reliever, it’s alsoaddictive, and people frequently develop a physical tolerance to it as well. Among overdose deaths in the U.S., the large majority involve the use of opioids. The Centers for Disease Control and Prevention (CDC) and other state and federal organizations are examining ways to deal with the opioid epidemic in the U.S., but so far there is little relief. People who use oxycodone recreationally do so because it produces a feeling of euphoria. Some people use oxycodone to self-medicate mental health conditions such as anxiety or depression.
Oxycodone Overdose: Signs, Symptoms & Treatment
The presence of risk factors for overdose should not prevent the proper management of pain in any given patient see WARNINGS AND PRECAUTIONS. Serious, life-threatening, or fatal respiratory depression may occur with the use of OXYCONTIN. Monitor for respiratory depression, especially during initiation of OXYCONTIN or following a dose increase. Instruct patients to swallow OXYCONTIN tablets whole; crushing, chewing, or dissolving OXYCONTIN tablets can cause rapid release and absorption of a potentially fatal dose of oxycodone see WARNINGS AND PRECAUTIONS. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should take oxycodone while you are pregnant or trying to get pregnant.
What should I do if I think someone is experiencing an opioid overdose?
- Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
- Discuss with the patient and caregiver the availability of naloxone for the emergency treatment of opioid overdose, both when initiating and renewing treatment with OXYCONTIN.
- Co-administration of OXYCONTIN (10 mg single dose) and the CYP3A4 inhibitor ketoconazole (200 mg BID) increased oxycodone AUC and Cmax by 170% and 100%, respectively see DRUG INTERACTIONS.
An overdose can occur if you take too much of an opioid or mix it with other addictive substances. Any opioid, either prescription or nonprescription, can lead to an overdose. The amount that’s “too much” varies based on your tolerance and the strength of the opioid. So, it’s important to follow prescribing instructions closely or avoid substances when you might not know what the dosage is. An oxycodone overdose death is a possibility if a person abuses this drug. It’s important for people who are prescribed oxycodone to follow the dosage instructions provided by their physician.
Before Calling Emergency
The following is an overview of what to know about oxycodone and overdoses. The most common cause of an oxycodone overdose is taking too much of the drug at once. The Centers for Disease Control and Prevention (CDC) states that taking more than morphine milligram equivalents (MME) per day can increase the risk of overdose. The amount of oxycodone it amphetamine addiction treatment takes to cause an overdose varies from person to person, and it depends on factors such as individual weight, height, and tolerance to the drug. People who have overdosed on oxycodone may also require additional emergency room treatment, such as oxygen therapy or artificial ventilation.
- This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines.
- It is not known whether these effects on fertility are reversible see Use In Specific Populations.
- Abuse of and addiction to opioids in some individuals may not be accompanied by concurrent tolerance and symptoms of physical dependence.
- Both immediate-release oxycodone and OxyContin are powerful pain relievers.
- They may also have sudden changes in their sleep patterns or eating habits.
OxyContin tablets contain larger amounts of oxycodone than immediate-release formulations because they are designed to release a steady supply of the drug over several hours. Respiratory depression can lead to hypoxia, resulting in reduced oxygen supply to the brain. https://gasbet22.co/is-a-blue-nose-a-sign-of-alcoholism/ Hypoxia resulting from opioid-induced respiratory depression can lead to coma, permanent brain damage, and death. It can even prove fatal if the person doesn’t know what’s happening or how to deal with the severity of the situation.